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dasatinib will improve the level or influence of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
hydrocortisone will lessen the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
stiripentol will lessen the extent or effect of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Keep track of Closely. Take into account reducing the dose of CYP2C19 substrates, if adverse reactions are seasoned when administered concomitantly with stiripentol.
lumefantrine will decrease the level or outcome of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
Accessible facts from posted observational studies of pregnant women exposed to benzodiazepines tend not to report a clear association with benzodiazepines and main beginning defects
eslicarbazepine acetate will lessen the extent or outcome of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
Liquor in combination with diazepam could induce a synergistic enhancement from the hypotensive Attributes of benzodiazepines and Alcoholic beverages.[94]
Observe Carefully (1)crofelemer boosts amounts of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. Crofelemer has the potential to inhibit CYP3A4 at concentrations expected within the gut; unlikely to inhibit systemically since minimally absorbed.
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Titrate IV dosage to wished-for sedative response, including slurring of speech, with gradual administration immediately just before process
Diazepam, as with other benzodiazepine medications, can result in tolerance, Bodily dependence, compound use ailment, and benzodiazepine withdrawal syndrome. Withdrawal from diazepam or other benzodiazepines frequently causes withdrawal signs and symptoms much like those found click here during barbiturate or Alcoholic beverages withdrawal.
ceritinib will boost the stage or influence of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
griseofulvin will decrease the level or impact of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
crizotinib boosts levels of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Dose reduction can be desired for coadministered medication which might be predominantly metabolized by CYP3A.